The museum collection of the Polotsk National Historical and Cultural Museum-Reserve includes 108,512 museum objects, 82,028 of them are objects of the primary fund (by 1 January 2021). The museum's fund is subdivided into collections 35 in number (painting, drawing, sculpture, decorative arts, glass, porcelain, weapons, clothing, furniture, old printed books, manuscripts, documents, printed editions, photo and phono materials, etc.). The biggest collections are: collection of numismatics, archaeological collection, collection of photo documents, and collection of printed editions.